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About Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a long-term inflammatory disease that leads to joint damage and excessive formation of new bone, particularly in a patient’s spinal vertebrae and lower hip joints. It is a painful and progressively debilitating condition that is caused by inflammation, and can have serious consequences, including irreversible spinal joint damage that reduces a patients’ mobility and quality of life. AS is a common type of spondyloarthritis (SpA), a family of long-term diseases of joints (inflammatory disease), which also includes psoriatic arthritis (PsA). AS occurs in up to 1% of the general population and typically affects young men and women 25 years or older. Certain genetic factors may increase a person’s risk of developing AS. Up to 70% of patients with severe AS can develop spinal fusion (bones grow together over joints). Patients with AS can become progressively disabled and unable to work, which may add to their reduced quality of life.

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